College football odds, lines, spreads: Picks, predictions, betting advice for Week 12, 2025 from proven model

Three undefeated FBS teams remain entering the Week 12 college football schedule, and they're all hosting unranked teams on Saturday. No. 1 Ohio State vs. UCLA (+34.5), No. 2 Indiana vs. Wisconsin (+29.5) and No. 3 Texas A&M vs. South Carolina (+17.5) all feature large Week 12 college football spreads, which could either intrigue or dissuade bettors from targeting these contests with college football predictions. If looking for smaller Week 12 college football lines, fortunately the three ranked matchups provide just that.

The fourth-ranked Alabama Crimson Tide are favored by 6 points over No. 11 Oklahoma, while also in the SEC, No. 5 Georgia is a 6.5-point favorite over No. 10 Texas. The other ranked contest has ninth-ranked Notre Dame giving 12.5 points, per the latest Week 12 college football odds, versus No. 23 Pitt, which just got back into the AP Poll after being unranked last week.

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Before making any college football picks for those games or others in Week 12, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 12 game, and the results are in. 

One of the college picks the model is high on during Week 12: the 11th-ranked Oklahoma Sooners (+6.5, 45.5) cover versus No. 4 Alabama in a 3:30 p.m. ET Saturday kickoff over 50% of the time. Another prediction: No. 16 Miami (-14.5, 55.5) covers against NC State in well over 50% of simulations Saturday at 3:30 p.m. ET, with the Over hitting well over 60% of the time in an A-rated pick.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple upsets in major games, including two ranked teams outright losing to unranked squads! 

So which college football teams should you back in Week 12, and which Top 25 teams fall? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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