College football odds, lines, spreads: Picks, predictions, betting advice for Week 11, 2025 from proven model

While there are just two ranked matchups you can make Week 11 college football picks on, that doesn't mean there aren't several other intriguing contests to construct your college football betting strategy around. Alabama vs. LSU is among the many rivalry games, with the Tide favored by 10.5 points per the Week 11 college football odds. There's also Notre Dame vs. Navy (+25.5), Clemson vs. Florida State (+2.5) and Oregon vs. Iowa (+6.5) as contests which will draw lots of interest with college football predictions.

As for those ranked games, they both involve the Lone Star State. No. 9 Texas Tech is favored by 11.5 points, per the Week 11 college football spreads, over No. 8 BYU at noon ET on Saturday. Additionally, the third-ranked Texas A&M Aggies are 6.5-point favorites over the 19th-ranked Missouri Tigers in a 3:30 p.m. ET kickoff. BYU and Texas A&M are two of the last four undefeated teams entering Week 11.

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Another of those undefeated squads is the top-ranked team in the land, Ohio State, which is also among the biggest of favorites on the Week 11 college football schedule. The Buckeyes are giving 29.5 points to the Purdue Boilermakers, and OSU shut out Purdue, 45-0, when the teams met last year (see more college football lines right here). 

Before making any college football picks for those games or others in Week 11, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it entered Week 10 on a profitable 47-33 combined run on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 11 game, and the results are in. 

One of the college picks the model is high on during Week 11: Ohio State (-29.5, 49.5) covers versus Purdue in a 1 p.m. ET Saturday kickoff well over 50% of the time. Another prediction: Clemson (-1.5, 56.5) covers against Florida State in well over 50% of simulations Saturday at 7 p.m. ET, with the Under hitting almost 60% of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple upsets in major games, including a Big Ten underdog outright winning! 

So which college football teams should you back in Week 11, and which Big Ten favorite falls? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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