The 2025 college football season begins on Saturday, Aug. 23, with the Week 0 college football schedule. There are four FBS matchups in Week 0, starting with Kansas State vs. Iowa State in Dublin, Ireland. That game kicks off at noon ET, with KSU favored by 3 points in the latest Week 0 college football odds and the over/under at 51.5. The Wildcats are -164 favorites on the money line (risk $164 to win $100).

The other matchups are Fresno State vs. Kansas (-14), Sam Houston vs. Western Kentucky (-10) and Hawaii vs. Stanford (+2.5) on CBS and Paramount+.

Before making any college football picks for those games or others in Week 0, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under picks in 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 0 game, and the results are in. 

One of the college picks the model is high on during Week 0: Stanford (+2.5) to cover against Hawaii in a 7:30 p.m. ET kickoff at Hawaii. Stanford covers well over 60% of the time, making it a strong Week 0 CFB pick.

The model has also made the call on who wins and covers in every FBS matchups, including a shocking updet!

So which college football teams should you back in Week 0, and which underdog starts the season off with a shocking upset? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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