College football odds, lines, spreads: Picks, predictions, betting advice for Championship Week 2025 from proven model

The college football postseason has arrived, with the conference championship schedule continuing with five more games on Saturday.

Alabama vs. Georgia has the Dawgs favored by 1.5 points in the SEC title game, per the latest Championship Week college football odds, as Bama is 4-0 all-time versus the Dawgs in the SEC Championship Game. Elsewhere, the ACC Championship Game pits Virginia vs. Duke (+4), and the Big Ten Title Game has Ohio State vs. Indiana (+4) in a matchup of No. 1 versus No. 2.

Texas Tech, meanwhile, is favored by 12.5 points over BYU in the Big 12 title. The Red Raiders ran roughshod in their matchup on Nov. 8, notching a 28-point win over a previously undefeated Cougars squad. Meanwhile, the Group of Five also has one more title game on Saturday with including Western Michigan listed as a 1.5-point favorites over Miami (OH) in the MAC Championship Game (see more college football lines right here). 

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

Before making any college football picks for Championship Week, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Championship Week game, and the results are in. 

One of the college picks the model is high on during Championship Week: No. 2 Indiana (+4, 46.5) covers against No. 1 Ohio State at Saturday at 7 p.m. ET, with the Under hitting more than 50% of the time. Another prediction: Duke (+4, 57.5) covers versus No. 16 Virginia in the ACC Championship Game on Saturday at 8 p.m. ET. The model projects the Blue Devils to cover almost 60% of the time.

The model has also made the call on who wins and covers in every other matchup, including calling for an underdog to win outright on Saturday! 

So which college football teams should you back in Championship Week, and which underdog wins straight-up? ... Join SportsLine now to see who wins and covers every single game, all from the model that has simulated every game 10,000 times!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.