College football odds, lines, spreads: Picks, predictions, betting advice for the 2026 CFP semifinals

The standard bowl games are in the books, but the College Football Playoff semifinals are set with Ole Miss vs. Miami (-3.5, 52.5) on Thursday in the 2026 Fiesta Bowl and then Oregon vs. Indiana (-3.5, 48.5) the following day in the Peach Bowl 2026 (see more college football lines right here). 

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Before making any CFP semifinal picks, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play of the CFP semis, and the results are in. 

One of the CFP picks the model is high on: The model projects that the Under (48.5) hits in Oregon vs. Indiana in the CFP semifinal on Friday. The model is projecting 46 combined points as the Under clears in 59% of simulations. 

The model has also made the call on who wins and covers in both game, including a spread pick in both games that hit well over 50% of the time!

So what are the best bets for the CFP semifinals? ... Join SportsLine now to see who wins and covers every single game, all from the model that has simulated every game 10,000 times!

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