The Week 4 college football schedule features three ranked matchups. No. 17 Texas Tech is a 3.5-point underdog against Utah, No. 11 Oklahoma is -7 against No. 22 Auburn and No. 9 Illinois is +6.5 against No. 19 Indiana.

Before making any Week 4 college football predictions, be sure to check out the Week 4 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. After opening this season 6-5, he's now on an 19-11 roll in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 4 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For Week 4, Casale is backing Michigan on the money line (-126) against Nebraska in a 3:30 p.m. ET game on CBS and Paramount+.

"Nebraska quarterback Dylan Raiola has struggled with turnovers in the past and that could be an issue again on Saturday versus an aggressive Michigan defense," Casale said. "The Cornhuskers hammered two creampuffs but played a close game with Cincinnati in the opener, winning 20-17. I don't have the Bearcats rated very high in my power rankings, so I'm still not sold on Nebraska's offense. I like the Wolverines to leave Lincoln with a hard-fought win."

Casale has also found another college football picks he loves, backing a team he says "is in a big revenge spot!" You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 4 in the 2025 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation who is on a 19-11 roll on his best bets!