Before making any Week 13 college football predictions, be sure to check out the college football picks and parlay from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

Now, he's turned his attention to the 2025 Week 13 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For this week, Casale is going Over 59.5 points in Oregon vs. USC. 

"This matchup just screams points," Casale said. "The last 10 meetings between USC and Oregon have produced at least 54 points with eight going over 60. I think we will see another high-scoring game on Saturday."

Casale has also found two other college football picks he loves, including backing a big underdog that "has a chance to steal a win!" You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 13 in the 2025 college football season, and which underdog should you back? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!

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