College basketball odds, lines, spreads, picks, predictions for Wednesday, Nov. 12: 3-way parlay pays almost 11-1

The 2025-26 college basketball schedule continues on Wednesday, Nov. 12, including two games involving ranked teams. The action continues all evening with the first tipoff at 6 p.m. ET and the last, Hawaii vs. Mississippi Valley State, tipping off at midnight ET. Some college basketball odds of note for Wednesday include No. 1 Houston vs. Oakland (+28.5), No. 12 Tennessee vs. North Florida (+40.5) and Minnesota vs. Missouri (-6.5).

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following could have seen HUGE returns!

One pick we'll give away: The model loves Saint Joseph's (+12.5) to cover in nearly 70% of simulations against Virginia Tech at 7 p.m. ET.

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