Clemson vs. Wake Forest odds, line, spread: Proven model reveals college basketball picks, predictions for Feb. 23, 2022

An ACC battle is on tap between the Clemson Tigers and the Wake Forest Demon Deacons at 7 p.m. ET on Wednesday at Littlejohn Coliseum. Clemson is 12-15 overall and 8-5 at home, while Wake Forest is 21-7 overall and 5-4 on the road. The Demon Deacons are ranked fifth in the ACC; Clemson is ranked 13th. 

The Demon Deacons are favored by 2.5 points in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over-under is set at 144.5. Before you make any Wake Forest vs. Clemson picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Clemson vs. Wake Forest 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Clemson vs. Wake Forest? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.