Clemson vs. North Carolina odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The 18th-ranked North Carolina Tar Heels look to secure a double-bye in the Atlantic Coast Conference Tournament and finish perfect at home when they battle the Clemson Tigers on Tuesday night. Clemson is coming off an 80-75 win over Louisville on Saturday, while North Carolina downed Virginia Tech 89-82 that same day. The Tigers (21-8, 11-5 ACC), who are tied with North Carolina for fourth in the conference, are 6-4 on the road this season. The Tar Heels (23-6, 11-5 ACC), who have won three in a row, are 17-0 on their home court in 2025-26. North Carolina will be without Caleb Wilson (wrist).

Tip-off from the Dean E. Smith Center in Chapel Hill, N.C., is set for 7 p.m. ET. North Carolina leads the all-time series 136-25, including a 60-2 edge in games played in Chapel Hill. North Carolina is a 3.5-point favorite in the latest Clemson vs. North Carolina odds from DraftKings Sportsbook, while the over/under for total points scored is 142.5. 

Before making any Clemson vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered Week 18 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 23-17 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Clemson vs. North Carolina 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Clemson vs. North Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!