The No. 4 Clemson Tigers host the No. 9 LSU Tigers on Saturday in one of the marquee games on the Week 1 college football schedule. Kickoff at Memorial Stadium in Clemson, S.C. is at 7:30 p.m. ET. Clemson, led by quarterback Cade Klubnik, is coming off a 10-4 season in 2024 that included a trip to the College Football Playoff. LSU is coming off a 9-4 season in 2024, and is entering the program's fourth season under head coach Brian Kelly. LSU is led by quarterback and Heisman Trophy contender Garrett Nussmeier. 

After opening at -3, Clemson is now a 4.5-point favorite in the latest LSU vs. Clemson odds, while the over/under for total points scored is 56.5. Clemson is a -202 (risk $202 to win $100) favorite on the money line, with LSU listed as a +168 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Clemson vs. LSU picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 235-152-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 112.82 units ($11,282.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for LSU vs. Clemson in their Week 1 matchup. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Clemson vs. LSU in their Week 1 matchup in Clemson, South Carolina and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 235-152-7, returning $11,282 for $100 bettors, betting on college football since 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates