Clemson vs. Duke odds, prediction: 2026 Atlantic Coast Conference Tournament men's college basketball picks from proven model

A trip to the Atlantic Coast Conference Tournament championship game will be on the line when the fifth-seeded Clemson Tigers battle the top-seeded Duke Blue Devils in Friday's semifinals. Clemson tripped up fourth-seeded North Carolina 80-79 in the quarterfinals on Thursday, while Duke survived 80-79 over eighth-seeded Florida State. The Tigers (24-9), who have won three straight, have never won an ACC Tournament championship, coming up second in 2008. The Blue Devils (30-2), who have won nine in a row, have won 23 ACC Tournament titles, including last season. Duke will be without Patrick Ngongba II (undisclosed) and Caleb Foster (foot), while Carter Welling (ACL) won't play for Clemson.

Tip-off from Spectrum Center in Charlotte, N.C., is set for 9:30 p.m. ET. Duke leads the all-time series 116-34, including a 67-54 win on Feb. 14. Duke is an 11.5-point favorite in the latest Clemson vs. Duke odds from DraftKings Sportsbook, while the over/under for total points scored is 134.5. Before making any Clemson vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered conference tournament week on a sizzling 14-2 run on top-ranked over/under picks dating back to last year, and is on an 28-21 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Clemson vs. Duke 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Clemson vs. Duke, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!