Clemson vs. Duke odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

Two of the Atlantic Coast Conference's top teams clash when the No. 20 Clemson Tigers face the fourth-ranked Duke Blue Devils on Saturday. Clemson is coming off a 76-66 loss to Virginia Tech on Wednesday, while Duke rolled to a 70-54 win at Pittsburgh on Tuesday. The Tigers (20-5, 10-2 ACC), who are tied with Virginia for second in the conference, are 6-2 on the road this season. The Blue Devils (22-2, 11-1 ACC), who lead the ACC, are 11-0 on their home floor. Players not expected to play include Clemson's Zac Foster (knee) and Duke's Ifeanyi Ufochukwu (undisclosed).

Tip-off from the Cameron Indoor Stadium in Durham, N.C., is set for noon ET. Duke leads the all-time series 115-34, but Clemson has won two of the last three matchups. Duke is an 11.5-point favorite in the latest Clemson vs. Duke odds from DraftKings Sportsbook, while the over/under for total points scored is 133.5. 

Before making any Clemson vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 15 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 11-5 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Clemson vs. Duke 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Clemson vs. Duke, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!