Cincinnati vs. Houston odds, prediction: 2026 Big 12 Conference men's college basketball picks from proven model

The 10th-ranked Houston Cougars go for the season sweep of the Cincinnati Bearcats when they meet in a Big 12 Conference matchup on Saturday afternoon. Cincinnati is coming off a 67-57 win over Baylor on Wednesday, while Houston defeated TCU 79-70 that same night. The Bearcats (11-10, 3-5 Big 12), who are 1-4 against ranked opponents, are 0-5 on the road this season. The Cougars (18-2, 6-1 Big 12), who are 15-0 against unranked foes, are 10-0 on their home court.

Tip-off from the Fertitta Center in Houston is set for noon ET. Cincinnati leads the all-time series 33-18, but Houston is 7-0 against the Bearcats in games played at the Fertitta Center. Houston is a 13.5-point favorite in the latest Cincinnati vs. Houston odds from DraftKings Sportsbook, while the over/under for total points scored is 134.5. Before making any Cincinnati vs. Houston picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Cincinnati vs. Houston 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Cincinnati vs. Houston, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!