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Chiefs vs. Jaguars prediction, odds: football expert reveals 2025 NFL Week 5 Monday Night Football picks, analysis

SportsLine expert Mike Tierney, who was 61-39-3 on his NFL picks in 2024, made his prediction for Chiefs vs. Jaguars in a Week 5 matchup at EverBank Stadium in Jacksonville, Fla.

ByPublished: Oct 06, 2025 11:09AM UTC . 2 min read

Teams looking to win their third consecutive game clash when the Kansas City Chiefs battle the Jacksonville Jaguars on Monday Night Football. Kansas City is coming off a 37-20 win over the Baltimore Ravens, while Jacksonville downed San Francisco 26-21 in Week 4. The Chiefs (2-2), who are 1-1 against AFC foes, are also 1-1 on the road this season. The Jaguars (3-1), who are 1-1 within the conference, are 2-0 on their home field in 2025.

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Kickoff from EverBank Stadium in Jacksonville, Fla., is set for 8:15 p.m. ET. Kansas City leads the all-time series 10-6, with the Chiefs winning each of the last eight meetings. Kansas City is a 3.5-point favorite in the latest Chiefs vs. Jaguars odds from SportsLine consensus, while the over/under for total points scored is 45.5. 

Before making any Chiefs vs. Jaguars picks or NFL predictions, you NEED to hear what SportsLine football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney is 235-189-13 in the NFL the past three seasons, returning $2,505 to $100 players. He hit 61.2% of his ATS picks (61-39-3) last season. He is also 33-17-1 (+1461) on his last 51 picks involving Jacksonville Jaguars games. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed Chiefs vs. Jaguars from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Chiefs vs. Jaguars on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Chiefs vs. Jaguars spread to jump on, all from the football expert who is 33-17 on Jacksonville picks!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

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Daniel Kohn

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