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Chiefs vs. Jaguars prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 5 Monday Night Football

The SportsLine projection model, which is on a 39-20 run on top-rated picks dating back to 2024, reveals its Kansas City Chiefs vs. Jacksonville Jaguars picks for Week 5 of Monday Night Football

ByPublished: Oct 06, 2025 11:07AM UTC . 2 min read

The Kansas City Chiefs and Jacksonville Jaguars will meet on ;Monday Night Football; to cap off NFL Week 5. Kansas City (2-2) has won two straight after starting off 0-2, while the Jags (3-1) have won three of their first four games for just the second time over the last 18 seasons. Kansas City has won eight straight games versus Jacksonville, including in the postseason.

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Kickoff is at 8:15 p.m. ET from EverBank Stadium in Jacksonville, Fla., where the two franchises have split eight all-time matchups. The latest Jaguars vs. Chiefs odds have Kansas City as 3.5-point favorites, and the over/under for total points scored is 45.5. The Chiefs are -198 favorites on the money line (risk $198 to win $100), while the Jags are +165 underdogs (risk $100 to win $165). 

Before making any Chiefs vs. Jaguars picks, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Jaguars vs. Chiefs on Monday Night Football.

We can tell you it's leaning Under the point total, but also says that one side of the spread hits in well over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Chiefs vs. Jaguars in NFL Week 5, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Jaguars vs. Chiefs line to back, all from the model that has gone 39-20 on top-rated picks since 2024!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

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Ross Kelly

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