The Los Angeles Chargers will face AFC West rivals the Kansas City Chiefs in a 2025 NFL Week 1 clash in Brazil on Friday, September 5. The Chiefs finished first in the division with a 15-2 record while the Chargers finished second at 11-6. Kansas City has won seven straight head-to-head meetings against Los Angeles going back to the 2021 season.

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Kickoff from Neo Quimica Arena in Sao Paulo is set for 8 p.m. ET. Kansas City is a 3-point favorite in the latest Chargers vs. Chiefs odds, while the over/under for total points scored is 47.5, up three points from the opener. 

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