Patrick Mahomes and the Kansas City Chiefs will kick off the post-Tyreek Hill era with a Week 1 showdown against the Arizona Cardinals on Sunday on Paramount+. Kickoff for Sunday's game from University of Phoenix Stadium in Glendale, Arizona is set for 4:25 p.m. ET. The Chiefs, who are 4-0 in Week 1 games with Mahomes under center, are a six-point favorite in the latest Cardinals vs. Chiefs odds from Caesars Sportsbook, and the over/under for total points is 53.5. Sunday's showdown will be televised on CBS and streamed live in select markets on Paramount+ with their MUST-HAVE Premium plan. Plus, you can watch games on ANY device!

You can catch all your local NFL on CBS games on Paramount+, which now has two plans. The Essential Plan costs $4.99 per month to access Paramount's catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream with no ads, on demand and the ability to download episodes for offline viewing. Both plans come with a free week to start, so sign up now here.

Before making any Cardinals vs. Chiefs picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Chiefs vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread hits well over 50% of simulations! You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Chiefs vs. Cardinals? And which side of the spread hits well over 50% of the time? ... Join SportsLine right now to see which side of the Cardinals vs. Chiefs spread to jump on, all from the model that has crushed its NFL picks!