The South Florida Bulls open American Conference play when they take on the Charlotte 49ers on Friday night. Charlotte is coming off a 28-17 loss to Rice on Sept. 18, while South Florida cruised to a 63-14 win over South Carolina State on Sept. 20. The 49ers (1-3, 0-1 American), who were 5-7 overall in 2024, will be playing their first true road game of the year. The Bulls (3-1, 0-0 American), who are 1-0 against unranked opponents, are 2-0 on their home field.

Kickoff from Raymond James Stadium in Tampa, Fla., is at 7 p.m. ET. South Florida leads the all-time series 2-0, including a 59-24 win last season at Charlotte. The Bulls are 28-point favorites in the latest Charlotte vs. South Florida odds, while the over/under for total points scored is 55.5 via SportsLine consensus. 

Before making any Charlotte vs. South Florida picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 37-24 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Charlotte vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

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