Teams looking to remain perfect after two weeks and contend for an AFC West title meet when the Los Angeles Chargers take on the Las Vegas Raiders on Monday Night Football. Los Angeles opened the regular season with a 27-21 win over Kansas City in Brazil, while Las Vegas downed New England 20-13. The Chargers (1-0), who took second in the division a year ago with an 11-6 mark, were 6-3 on the road last year. The Raiders (1-0), who were just 4-13, were 2-6 on their home field in 2024. They are now coached by former Seattle Seahawks coach Pete Carroll.

Kickoff from Allegiant Stadium in Las Vegas is set for 10 p.m. ET. The Raiders lead the all-time series 69-60-2, but the Chargers have won three of the last four meetings. Los Angeles is a 3.5-point favorite in the latest Chargers vs. Raiders odds from SportsLine consensus, while the over/under for total points scored is 46.5. 

Before making any Chargers vs. Raiders picks or NFL predictions, you NEED to hear what SportsLine football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney is 235-189-13 in the NFL the past three seasons, returning $2,505 to $100 players (every bet 1 unit). He hit 61.2 percent of his ATS picks (61-39-3) last season. He is also 13-4 (+865) on his last 17 picks involving Las Vegas Raiders games. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed Chargers vs. Raiders from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Chargers vs. Raiders on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Chargers vs. Raiders spread to jump on, all from the football expert who was 61-39-3 last season on his NFL picks!