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Chargers vs. Raiders line, odds: Proven model releases spread pick for 2025 NFL Week 2 Monday Night Football

The SportsLine projection model, which is on a 33-17 run on top-rated picks dating back to 2024, reveals its picks for the Las Vegas Raiders vs. Los Angeles Chargers on Monday Night Football in NFL Week 2

ByPublished: Sep 16, 2025 12:57AM UTC . 2 min read

Familiar foes face off on the Monday Night Football stage as the Raiders welcome the Los Angeles Chargers to Sin City in NFL Week 2. These AFC West rivals enter Week 2 in the win column, with the Chargers upsetting the Kansas City Chiefs in Sao Paulo 27-21 and the Raiders beating the Patriots in New England 20-13. Los Angeles has won four of the last five head-to-head meetings with Las Vegas.

Kickoff from Allegiant Stadium is set for 10 p.m. ET. Los Angeles is a 3.5-point favorite in the latest Chargers vs. Raiders odds, and the over/under for total points scored is 46.5. The Chargers -188 favorites on the money line (risk $188 to win $100), while the Raiders are +157 underdogs (risk $100 to win $157). 

Before making any Raiders vs. Chargers picks or 2025 NFL Week 2 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Raiders vs. Chargers on Monday Night Football.

We can tell you it's leaning Under the point total, but also says that one side of the spread hits in more than 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Raiders vs. Chargers in NFL Week 2, and which side of the spread hits in more than 50% of simulations? ... Join SportsLine RIGHT NOW to see which side of the Chargers vs. Raiders line to back, all from the model that has gone 33-17 on top-rated picks since 2024!

GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

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Chelena Goldman

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