Two West Coast teams with hopes to make the playoffs will collide when the San Francisco 49ers host the Los Angeles Chargers in the Week 10 Sunday Night Football game at Levi's Stadium. The 49ers (4-4), who reached the NFC Championship Game last year, sit in second place in the NFC West, 1 1/2 games behind the surprising Seahawks (6-3). The Chargers (5-3) are in second place in the AFC West, one game behind the Chiefs (6-2). Kickoff is set for 8:20 p.m. ET.

San Francisco is a 7.5-point favorite in the latest 49ers vs. Chargers odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before you make any Chargers vs. 49ers picks or any other NFL predictions, you NEED to see which side R.J. White is on. 

White, a Fantasy and gambling editor for CBS Sports, consistently crushes picks against-the-spread and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 19-7-1 on his last 27 against-the-spread picks involving the Chargers, meaning he's well-qualified for this selection.

He's well-known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. White also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed White is WAY UP.

White knows that San Francisco's running attack has a favorable matchup going up against Los Angeles' defense. The Chargers have given up 5.7 yards per carry this season, which ranks dead-last in the NFL. They also allow 145.5 rushing yards per game; just three teams - the Bears, Lions and Texans - give up more.

White also has taken into account that Los Angeles has one of the NFL's most versatile weapons in Austin Ekeler. The 5-foot-10, 200-pound running back leads the NFL with 10 total touchdowns. He has rushed for a touchdown in five consecutive games, the longest such active streak in the NFL.

Now, White has locked in another confident against the spread pick, for 49ers vs. Chargers. We can tell you he's leaning Under the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Chargers vs. 49ers on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the 49ers vs. Chargers spread to jump on, all from the expert who's an amazing 19-7 on against-the-spread picks involving the Chargers!