The No. 12 Oklahoma State Cowboys host the Central Michigan Chippewas in the season opener for both teams at 7 p.m. ET on Thursday. Oklahoma State is favored by 21.5 points at Caesars Sportsbook, while the over/under is set at 58 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Central Michigan vs. Oklahoma State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

The model knows Central Michigan is on an active five-game winning streak. The Chippewas won nine games last season, most for the program since 2009, and Central Michigan has a potent offense returning for 2022. Running back Lew Nichols is the headliner, leading FBS with 1,848 rushing yards last season, and he exceeded 100 yards in the final eight games of the campaign. The model also knows that Oklahoma State tied a school record with 12 wins last season, including a victory over Notre Dame in the Fiesta Bowl. The Cowboys were perfect at home in 2021, and Oklahoma State has won seven consecutive season openers and 12 straight games against non-Power 5 opponents.

Now, it has set its sights on Central Michigan vs. Oklahoma State. We can tell you the model is leaning Under the total, and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Central Michigan vs. Oklahoma State? And which side of the spread hits in well over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Central Michigan vs. Oklahoma State spread you should be all over Thursday, all from the model on a roll on college football picks!