Celtics vs. Cavaliers odds, line, spread, time: 2025 NBA picks, October 29 predictions from proven model

The top two seeds from last year's Eastern Conference will square off on Wednesday's NBA schedule as the Cleveland Cavaliers visit the Boston Celtics. The Cavs (3-1) had the best record in the East a year ago and have won three straight games in the 2025-26 NBA season after dropping their opener. The Celtics (1-3) were the No. 2 seed last season and are coming off their first victory of this year after losing their first three contests. The teams split four matchups last season..

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Tipoff is set for 7 p.m. ET from TD Garden in Boston. The latest Cavaliers vs. Celtics odds, according to the SportsLine consensus, have Cleveland as the 3.5-point favorite. The over/under is 234.5 points.

Before entering any Celtics vs. Cavaliers picks, you'll want to see the NBA predictions from the model at SportsLine.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters Week 2 of the 2025-26 NBA season on a sizzling 161-120 roll on all top-rated NBA picks, returning nearly $4,000. It also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following could have seen HUGE returns!

The model has simulated Celtics vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits almost 70% of the time!

So who wins Cavs vs. Celtics, and which side of the spread hits almost 70% of the time? Join SportsLine right now to see which side of the Celtics vs. Cavs spread you need to jump on, all from the computer model that has crushed its NBA picks!

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