Cavaliers vs. Pistons odds, line: Proven model reveals picks for NBA Eastern Conference semifinal Game 2 matchup on Thursday, May 7

The fourth-seeded Cleveland Cavaliers look to knot their best-of-seven series at 1-1 when they battle the Detroit Pistons in Game 2 of their Eastern Conference semifinal matchup on Thursday. Detroit won Tuesday's series opener 111-101. The Cavaliers (52-30), who are looking to reach the conference finals for the first time since 2017-18, are 25-20 on the road this season, including the playoffs. The Pistons (60-22), who are looking to reach the conference finals for the first time since 2007-08, are 35-10 on their home court in 2025-26.

Tip-off from Little Caesars Arena in Detroit is set for 7 p.m. ET. The Cavaliers lead the all-time postseason series 15-7, including 12 of the past 13 meetings. The Pistons are a 3.5-point favorite in the latest Cavaliers vs. Pistons odds from FanDuel Sportsbook, while the over/under for total points scored is 215.5. 

Before making any Cavaliers vs. Pistons picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Cavaliers vs. Pistons 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits well over 60% of the time!

Who wins Cavaliers vs. Pistons, and which side of the spread hits well over 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!