Cavaliers vs. Hornets prediction, odds, line: Proven model reveals 2026 NBA picks for Jan. 21

The Wednesday NBA schedule gets underway with an Eastern Conference matchup between the Cleveland Cavaliers and the Charlotte Hornets. The Cavs are 24-20 and coming off a loss to the Thunder last time out. The Hornets are 16-27, but have won three of their last five. 

Tipoff is at 7 p.m. ET from the Spectrum Center in Charlotte. The latest Hornets vs. Cavaliers odds list Cleveland as the 2.5-point favorite, while the over/under is 236.5.

Before making any Cavaliers vs. Hornets picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 14 of the 2025-26 NBA season on a sizzling 35-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Suns vs. Sixers 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits in well over 50% of simulations!

Who wins 76ers vs. Suns, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 35-15 roll on top-rated NBA spread picks!