Cavaliers vs. Bulls odds, line: Proven model reveals picks for NBA matchup on December 17

Teams looking to get back on track meet when the Cleveland Cavaliers face the Chicago Bulls in a key Central Division matchup on Wednesday night. Cleveland is coming off a 119-111 loss to the Charlotte Hornets on Sunday, while Chicago dropped a 114-104 decision to the New Orleans Pelicans that same day. The Cavaliers (15-12), who are 4-6 over the past 10 games, are 6-5 on the road this season. The Bulls (10-15), who are 2-8 over the past 10 games, are 6-6 on their home court. Cleveland center Evan Mobley (calf) and forward Larry Nance Jr. (calf) are both not expected to play.

Tip-off from United Center in Chicago is set for 8 p.m. ET. The Bulls lead the all-time series 133-106, but the Cavaliers have won the last five meetings, including a 128-122 decision on Nov. 8. Cleveland is a 5-point favorite in the latest Cavaliers vs. Bulls odds from SportsLine consensus, while the over/under for total points scored is 241.5.

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Before making any Cavaliers vs. Bulls picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 9 of the 2025-26 NBA season on a sizzling 29-14 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Cavaliers vs. Bulls 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread hits in well over 50% of simulations!

Who wins Cavaliers vs. Bulls, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 29-14 roll on top-rated NBA picks!

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