Cardinals vs. Tigers odds, line, prediction: Proven MLB model reveals Sunday Night Baseball picks

An interleague clash takes place on Sunday Night Baseball as the Detroit Tigers host the St. Louis Cardinals. Both teams are 4-4 in the 2026 MLB season, with Detroit 2-0 at home and St. Louis 0-2 on the road. The Tigers have claimed the first two games of this three-game set, shutting out the Cardinals 4-0 on Friday and then prevailing 11-6 on Saturday. Kyle Leahy (0-1, 7.20 ERA) will start for the Cards, with Keider Montero making his season debut for the Tigers.

First pitch is at 7:20 p.m. ET from Comerica Park in Detroit. The latest Tigers vs. Cardinals odds list Detroit as the -138 favorite on the money line (risk $138 to win $100). The over/under for total runs is 8.

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The model has simulated Tigers vs. Cardinals 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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