Cardinals vs. Tigers odds, line, prediction: 2026 MLB picks for Saturday afternoon from proven model

The St. Louis Cardinals will look to even their three-game series at 1-1 when they battle the Detroit Tigers in an interleague matchup on Saturday. The Tigers posted a 4-0 win over St. Louis in Detroit's home opener on Friday. The Cardinals (4-3), who had a two-game winning streak snapped, were fourth in the National League Central at 78-84 a year ago. The Tigers (3-4), who stopped a four-game losing streak, were second in the American League Central at 87-75 in 2025.

First pitch from Comerica Park in Detroit is set for 1:10 p.m. ET. The Tigers lead the all-time series 41-28, including wins in five of the last six meetings. Detroit is a -160 favorite on the money line (risk $160 to win $100) in the latest Cardinals vs. Tigers odds, while the total number of runs Vegas thinks will be scored, or the over-under, is 8. 

Before making any Cardinals vs. Tigers picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled making home run prop picks in 2025, returning nearly 30 units of profit! Anybody following could have seen strong returns!

The model has simulated Cardinals vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

Who wins Cardinals vs. Tigers, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Cardinals vs. Tigers money line you should be all over, all from the model on a 35-29 roll on top-rated MLB money-line picks!