The Cincinnati Reds (16-15) and the St. Louis Cardinals (14-17) wrap up an NL Central collision on Thursday. These two played a doubleheader on Wednesday, where the Cardinals won both matchups. St. Louis outscored the Reds 15-1 in the two victories.

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First pitch is scheduled for 12:40 p.m. ET at Great American Ball Park in Cincinnati. The Reds are the -118 money-line favorites (bet $118 to win $100) in the latest Cardinals vs. Reds odds, while the Cardinals are +100 underdogs (bet $100 to win $100). The over/under for total runs scored is 8.5 in the latest MLB odds. 

Before you make any Cardinals vs. Reds picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 6 of the 2025 MLB season on a 17-11 run on top-rated MLB picks (+276). Anybody following could have seen strong returns!

The model has simulated Cardinals vs. Reds 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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