Cardinals vs. Reds odds, line, prediction: 2026 MLB picks for Game 1 on Monday, Aug. 17, from proven model
SportsLine's projection model, which entered Week 22 of the MLB season on a 49-31 run, has locked in its MLB predictions for the St. Louis Cardinals vs. Cincinnati Reds in Game 1 on Monday afternoon

The St. Louis Cardinals will look to stay hot when they battle the National League Central Division-rival Cincinnati Reds in Game 1 of a day-night doubleheader on Monday afternoon. The game is a makeup from a game postponed by rain on May 24. St. Louis is coming off an 11-4 win over the Chicago Cubs on Sunday, while Cincinnati dropped a 7-1 decision to Miami. The Cardinals (63-61), who are third in the division, are 31-27 on the road this season. The Reds (59-64), who are fifth in the NL Central, are 30-33 on their home field.
