The No. 23 BYU Cougars will host the West Virginia Mountaineers on Friday night in a Big 12 showdown. BYU (4-0, 1-0 in Big 12) won its conference opener over Colorado last week, 24-21, and is one of 20 undefeated teams left standing in FBS. WVU (2-3, 0-2) is coming off back-to-back Big 12 losses, last falling to Utah, 48-14, in Week 5. West Virginia won the two previous meetings between the teams, with the last coming in 2023.

Kickoff is at 10:30 p.m. ET from LaVell Edwards Stadium in Provo, Utah. The Cougars are 20.5-point favorites in the latest BYU vs. West Virginia odds, while the over/under for total points scored is 46.5 via SportsLine consensus. 

Before making any West Virginia vs. BYU picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 37-24 combined on money-line and over/under picks since the beginning of 2024. Anyone following it could have seen impressive returns.

The model has simulated West Virginia vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 70% of simulations.

So who wins BYU vs. West Virginia, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the West Virginia vs. BYU spread you need to jump on, all from the computer model that has crushed its college football picks!