Butler vs. St. John's odds, prediction: 2026 Big East men's college basketball picks from proven model

The Butler Bulldogs will look to win their fourth game in a row when they take on the 25th-ranked St. John's Red Storm in a key Big East Conference matchup on Wednesday night. Butler is coming off an 87-76 win over Marquette on Friday, while St. John's downed Xavier 88-83 on Saturday. The Bulldogs (13-7, 4-5 Big East), who are tied for fifth in the conference, are 1-4 on the road this season. The Red Storm (15-5, 8-1 Big East), who are second in the Big East, are 9-2 on their home court.

Tip-off from Madison Square Garden in New York is set for 7 p.m. ET. St. John's leads the all-time series 17-11, including an 84-70 win on Jan. 6. St. John's is a 12.5-point favorite in the latest Butler vs. St. John's odds from DraftKings Sportsbook, while the over/under for total points scored is 162.5. 

Before making any Butler vs. St. John's picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Butler vs. St. John's 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits well over 50% of the time!

So who wins Butler vs. St. John's, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!