The No. 6 Michigan Wolverines open their regular season against the MAC favorite Buffalo Bulls in non-conference college basketball action on Wednesday night. Tip-off is set for 6:30 p.m. ET from Crisler Arena in Ann Arbor, Mich. Michigan is favored by 12.5 points at Caesars Sportsbook, while the Over-Under is set at 153.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Buffalo vs. Michigan picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five years, the proprietary computer model has generated an impressive profit of $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows the Wolverines are led by sophomore center Hunter Dickinson, who led the team in scoring at 14.1 points per game and in rebounding (7.4). He was the first Michigan freshman to lead the team in scoring since Ignas Brazdelikis (14.8 points in 2018-19) and first to lead in rebounding since Mitch McGary (6.3 in 2012-13). He earned seven Big Ten Freshman of the Week honors and was a consensus second team All-American, as well as the Big Ten's Freshman of the Year. Dickinson had 23 double-figure scoring games, including nine 15-plus point games and five 20-plus games, including a career-best 28 points against No. 19 Minnesota on Jan. 6.

The model also knows the Bulls are coming off a 105-54 victory over Medaille in its lone exhibition game. They return senior forward Jeenathan Williams, who led the team in scoring in 2020-21. In 25 games played, Williams averaged 17.6 points, 6.8 rebounds, 2.4 assists and 1.1 steals per game, hitting on 48.6 percent of his shots from the floor, including 38.6 from 3-point range. He was named to the preseason All-MAC first team and is just 76 points from becoming the 24th Buffalo player to reach the 1,000-point mark.  

Now, it has set its sights on Buffalo vs. Michigan. and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Buffalo vs. Michigan? And which side of the spread cashes in well over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Buffalo vs. Michigan spread you should be all over Wednesday, all from the model on a roll on college basketball picks!