Buffalo vs. Central Michigan MACtion odds, line: 2025 college football picks for Week 12 predictions from proven model

Teams looking to have a say in the Mid-American Conference title chase meet when the Buffalo Bulls battle the Central Michigan Chippewas in MACtion on Wednesday night. Buffalo is coming off a 28-3 win at Bowling Green on Nov. 1, while Central Michigan dropped a 24-21 decision to Western Michigan that same day. The Bulls (5-4, 4-1 MAC), who are tied with three other teams for first in the conference, are 3-1 on the road this season. The Chippewas (5-4, 3-2 MAC), who are tied for fifth in the league, are 3-0 on their home field.

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Kickoff from Kelly/Shorts Stadium in Mount Pleasant, Mich., is at 7 p.m. ET on CBS Sports Network. Central Michigan leads the all-time series 8-4, including a 3-1 edge in games played at Mount Pleasant. The Chippewas are 1.5-point favorites in the latest Buffalo vs. Central Michigan odds, while the over/under for total points scored is 44.5.

Before making any Buffalo vs. Central Michigan picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Buffalo vs. Central Michigan 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 60% of simulations.

So who wins Buffalo vs. Central Michigan, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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