Buccaneers vs. Panthers prediction, odds: Proven model releases 2026 NFL Week 18 picks for Saturday matchup

The NFC South winner will be decided in the Week 18 Saturday matchup between the Carolina Panthers and Tampa Bay Buccaneers. Carolina (8-8) will clinch the division with a victory, regardless of what happens in Sunday's NFL games. Meanwhile, Tampa (7-9) must win to have a chance for the divisional crown, though it also needs Atlanta to lose to New Orleans in Week 18. Whichever team wins the division will be the NFC's No. 4 seed.

Kickoff is at 4:30 p.m. ET from Raymond James Stadium in Tampa, Fla. The latest Buccaneers vs. Panthers odds have Tampa favored by 2.5 points, while the over/under for total points is 44.

Before making any Panthers vs. Buccaneers picks, or 2026 NFL Week 18 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Buccaneers vs. Panthers.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits in well over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Panthers vs. Buccaneers in NFL Week 18, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Buccaneers vs. Panthers line to back, all from the model that has gone 53-37 on top-rated picks since 2024!

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