The Week 14 NFL schedule features a battle between NFC Super Bowl contenders when Tom Brady and the Tampa Bay Buccaneers (6-6) hit the road to take on Brock Purdy and the San Francisco 49ers (8-4) on Sunday at Levi's Stadium. The Bucs are coming off a thrilling 17-16 come from behind win over the New Orleans Saints on Monday Night Football, while the 49ers are riding aa five-game winning streak after a dominating 33-17 win over the Miami Dolphins. San Francisco did lose quarterback Jimmy Garoppolo for the year with a broken foot, however. Tampa Bay is 3-8-1 against the spread, while San Francisco is 7-5 ATS in 2022. 

Kickoff is at 4:25 p.m. ET. San Francisco is favored by 3.5 points in the latest 49ers vs. Buccaneers odds from Caesars Sportsbook, and the over/under is set at 38. Before making any Buccaneers vs. 49ers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 14 of the 2022 NFL season on an incredible 156-112 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Buccaneers vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins 49ers vs. Buccaneers? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.