A series win will be on the line when the Toronto Blue Jays battle the Pittsburgh Pirates in an interleague matchup on Wednesday afternoon. The Blue Jays (74-53), who lead the American League East division, are 32-32 on the road this season. The Pirates (53-74), who are fifth in the National League Central, are 35-30 on their home field in 2025.

First pitch from PNC Park in Pittsburgh is set for 12:35 p.m. ET. The Blue Jays have won eight of the past 10 meetings with the Pirates. Toronto is a -152 favorite on the money line (risk $152 to win $100) in the latest Blue Jays vs. Pirates odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8 in the latest MLB odds. 

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The model has simulated Blue Jays vs. Pirates 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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