The Seattle Mariners will look to put the Toronto Blue Jays on the brink of elimination when they meet in Game 3 of their best-of-seven American League Championship Series on Wednesday. Seattle seized a 2-0 series lead with a 10-3 win in Toronto on Monday. The Blue Jays (94-68), who are looking to reach their first World Series since winning it all in back-to-back seasons in 1992 and 1993, are 41-42 on the road this season, including playoffs. The Mariners (90-72), who are seeking their first-ever World Series appearance, are 53-31 on their home field in 2025. Toronto shortstop Bo Bichette (knee) is not expected to play.

First pitch from T-Mobile Park in Seattle is set for 8:08 p.m. ET. The Mariners have won four of the past seven meetings with the Blue Jays. Seattle is a -130 favorite on the money line (risk $130 to win $100) in the latest Blue Jays vs. Mariners odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 7 in the latest MLB odds. 

Before you make any Blue Jays vs. Mariners picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the ALCS and NLCS rounds of the 2025 MLB playoffs a profitable 35-29 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Blue Jays vs. Mariners 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Blue Jays vs. Mariners, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 35-29 roll on top-rated MLB money-line picks!