Bills vs. Texans prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 12 Thursday Night Football

Two AFC hopefuls will kick off NFL Week 12 as the Buffalo Bills visit the Houston Texans on 'Thursday Night Football.' Buffalo (7-3) sits in second place of the AFC East and has won three of its last four, with it coming off a 44-32 win over Tampa on Sunday. Houston (5-5) is third in the AFC South, has also won three of four and most recently notched a 16-13 win over Tennessee in Week 11. Houston won the last matchup as it defeated Buffalo, 23-20, at home in 2024. Houston quarterback C.J. Stroud (concussion) has been ruled out, as has Bills tight end Dalton Kincaid (hamstring), while receiver Keon Coleman is inactive for the second straight week. The Bills are currently the No. 5 seed in the AFC, while Houston is the No. 8 seed.

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Kickoff is at 8:15 p.m. ET from NRG Stadium in Houston. The Texas have won five straight home games versus Buffalo. The latest Bills vs. Texans odds have Buffalo as the 5-point favorites. The over/under for total points scored is 44.5. Buffalo is at -265 on the money line (risk $265 to win $100), while Houston is at +215 (risk $100 to win $215).

Before making any Texans vs. Bills picks or Thursday Night Football predictions, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Bills vs. Texans on Thursday Night Football.

We can tell you the model is going Under the point total, but also says one side of the spread hits over 50% of the time in an A-rated pick! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Texans vs. Bills in NFL Week 12, and which side of the spread hits in over 50% of simulations in an A-rated pick? ... Join SportsLine RIGHT NOW to see which side of the Bills vs. Texans line to back, all from the model that is 48-33 on top-rated picks since 2024!

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