AFC East foes will collide when the Buffalo Bills (8-3) and the New England Patriots (6-5) battle on Thursday Night Football. Buffalo has won two straight games, while New England had its three-game win streak halted on Thanksgiving. Kickoff is 8:15 p.m. ET. Buffalo is a four-point favorite in the latest Bills vs. Patriots odds from Caesars Sportsbook while the over/under for total points scored is 44.

Before you make any Bills vs. Patriots picks or NFL predictions, you need to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2022 NFL season on an incredible 155-110 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Buffalo quarterback Josh Allen owns arguably the strongest arm in the league while also having pinpoint accuracy. The Wyoming product is second in passing yards (3,183), tied for second in passing touchdowns (23) and third in QBR (73.6). 

The model also New England's defense is extremely disciplined and well-coached by head coach Bill Belichick. The Patriots have a powerful pass rush with stout help in the secondary. New England ranks fourth in total defense (307.8), but ninth in both pass defense (198.5) and run defense (109.3).

Now, it has set its sights on Bills vs. Patriots. We can tell you the model is leaning Over on the point total, and it also says one side of the spread hits in over 50% of simulations! You ABSOLUTELY need to see it before locking in any TNF picks!

So who wins Bills vs. Patriots on Thursday Night Football? And which side of the spread hits in over 50% percent of simulations? Join SportsLine now to find out which side of the Patriots vs. Bills spread to back, all from the model on a 155-110 roll!