Playoff positioning in the AFC will be at stake when the Buffalo Bills meet the New England Patriots on Monday Night Football. Kickoff is set for 8:15 p.m. ET. Buffalo is a 7.5-point favorite in the latest odds from William Hill Sportsbook, while the Over-Under for total points scored is 47.

Before locking in any Bills vs. Patriots picks or NFL predictions, you NEED to see what SportsLine's all-time No. 1 NFL expert, Mike Tierney, has to say. 

A national sportswriter whose work appears in The New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. He prefers to evaluate each game from the underdog's point of view and has used that philosophy to dominate the NFL, going 66-44 against the spread in 2019 and 63-46 in 2018. Tierney entered the 2020 season with a 282-222 record at SportsLine (2016-19) on all NFL picks, returning $3,704 to $100 players.

He also has had a sharp eye for the tendencies of the Bills, posting a stunning 10-4 record in his last 14 against-the-spread picks involving Buffalo! Anyone who has followed him is WAY UP.

Now he's studied Patriots vs. Bills from every possible angle. We can tell you he's leaning Under the total, and he's also found a critical X-factor that makes one side of the spread hit HARD! You ABSOLUTELY need to see it before you lock in your own picks.

So who wins Bills vs. Patriots on Monday Night Football? And what critical X-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the Patriots vs. Bills spread you should be all over, all from the expert who's 10-4 on his last 14 spread picks involving Buffalo!