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Bills vs. Falcons prediction, odds: football expert reveals 2025 NFL Week 6 Monday Night Football picks, analysis

SportsLine expert Zack Cimini, who is on a 17-4 roll on Falcons picks, made his prediction for Bills vs. Falcons in a Week 6 matchup at Mercedes-Benz Stadium in Atlanta

ByPublished: Oct 13, 2025 1:12PM UTC . 2 min read

The Buffalo Bills look to get back into the win column when they take on the Atlanta Falcons on Monday Night Football. Buffalo is coming off a 23-20 loss to the New England Patriots in Week 5, while Atlanta downed Washington 34-27 on Sept. 28, before last week's bye. The Bills (4-1), who are first in the AFC East, are 1-0 on the road this season. The Falcons (2-2), who are second in the NFC South, are 1-1 on their home field.

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Kickoff from Mercedes-Benz Stadium in Atlanta is set for 7:15 p.m. ET. Atlanta leads the all-time series 7-6, but have not beaten Buffalo since 2013. The Bills are 3.5-point favorites in the latest Bills vs. Falcons odds, while the over/under for total points scored is 50 via SportsLine consensus. 

Before making any Bills vs. Falcons picks, be sure to check out what SportsLine expert Zack Cimini has to say.    

A Las Vegas handicapper who's never afraid to buck conventional wisdom, Cimini shines in multiple sports. He especially has his finger on the pulse of the Atlanta Falcons. In his last 21 selections involving the Falcons, he is 17-4 (+1260). Anyone who has followed him could be WAY up!

Now, Cimini has analyzed Bills vs. Falcons from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Bills vs. Falcons on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Bills vs. Falcons spread to jump on, all from the football expert who is 17-4 on Atlanta picks!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

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Daniel Kohn

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