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Bills vs. Dolphins prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 3 Thursday Night Football

The SportsLine projection model, which is 37-17 on top-rated picks since last season, reveals Dolphins vs. Bills picks for Thursday Night Football in NFL Week 3

ByPublished: Sep 18, 2025 11:05PM UTC . 2 min read

Josh Allen and the Buffalo Bills will look to continue their dominance over the Miami Dolphins when the divisional rivals square off on Thursday Night Football. Buffalo has won 13 of the last 14 meetings with Miami, including six straight, counting the postseason. The Bills (2-0) are coming off a 30-10 win over the Jets, while the Dolphins (0-2) fell 33-27 at home to the Patriots, making them 0-2 for the first time in six years. Josh Allen is 13-2 in his career versus the Dolphins, including the playoffs.

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Kickoff is at 8:15 p.m. ET from Highmark Stadium in Orchard Park, N.Y. Buffalo is an 11.5-point favorite in the latest Bills vs. Dolphins odds. The over/under for total points scored is 50.5, making it one of three Week 3 NFL games with a total over 50. Buffalo is a -826 favorite on the money line (risk $826 to win $100), while Miami is at +560 (risk $100 to win $560).

Before making any Dolphins vs. Bills picks or Thursday Night Football predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 37-17 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Bills vs. Dolphins on Thursday Night Football.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits in almost 60% of simulations in an A-rated pick! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

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Ross Kelly

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