Bills vs. Broncos prediction, odds: Proven model releases 2026 NFL divisional round picks for Saturday matchup

The No. 1 seed Denver Broncos will take the field for the first time in the 2026 NFL playoffs when they host the Buffalo Bills in Saturday's divisional round contest. Denver (14-3) ended the year with back-to-back wins before having a bye over Wild Card Weekend, while Buffalo (12-5) is coming off a 27-24 Sunday victory over the Jaguars. The Bills defeated the Broncos, 31-7, at home in last season's Wild Card Round.

Kickoff is at 4:30 p.m. ET from Empower Field at Mile High in Denver. The latest Bills vs. Broncos odds have Buffalo favored by 1.5 points, giving this the slimmest NFL spread of the divisional round. The over/under for total points is 46.5. 

Before making any Broncos vs. Bills picks, or 2026 NFL playoff predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the Divisional Round of the 2026 NFL playoffs on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Bills vs. Broncos.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits in well over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Broncos vs. Bills in the NFL divisional round, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Bills vs. Broncos line to back, all from the model that has gone 53-37 on top-rated picks since 2024!

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