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Bears vs. 49ers prediction, odds, line, spread: Proven model reveals NFL picks, best bets for Week 1, 2022

The SportsLine projection model simulated San Francisco vs. Chicago and released its picks, predictions, and best bets
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The Chicago Bears open their 2022 NFL season playing host to the San Francisco 49ers at 1 p.m. ET on Sunday at Soldier Field. This game is one of 16 on the Week 1 NFL schedule and features two teams looking to get off to a fast start. Justin Fields enters his first full season as the Bears' starting quarterback, after the former Ohio State standout started 10 games as a rookie in 2021. On the other side, Trey Lance will be making his third career NFL start after filling in for Jimmy Garoppolo for two games as a rookie last year. The Bears ended last year third in the NFC North, while San Francisco finished third in the NFC West. 

San Francisco is favored by 6.5 points in the latest Bears vs. 49ers odds from Caesars Sportsbook, and the over/under is set at 40. Before you make any 49ers vs. Bears picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 last season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Bears vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Bears vs. 49ers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.

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SportsLine Staff

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