Auburn vs. Oklahoma odds, line: 2025 college football picks for Week 4 predictions from proven model

Unbeaten and ranked teams kick off their Southeastern Conference schedule when the No. 22 Auburn Tigers battle the No. 11 Oklahoma Sooners on Saturday. Auburn is coming off a 31-15 win over South Alabama, while Oklahoma downed Temple 42-3 in Week 3. The Tigers (3-0), who tied for 13th in the conference with Oklahoma at 2-6 and were 5-7 overall last year, are 2-3 on the road since the start of last season. The Sooners (3-0), who were 6-7 overall last year, are 7-2 on their home field since the start of 2024.

Kickoff from Gaylord Family Oklahoma Memorial Stadium in Norman, Okla., is at 3:30 p.m. ET. Oklahoma leads the all-time series 3-0, including a 27-21 win last season. The Sooners are 6.5-point favorites in the latest Auburn vs. Oklahoma odds, while the over/under for total points scored is 46.5 via SportsLine consensus. 

Before making any Auburn vs. Oklahoma picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 32-20 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Auburn vs. Oklahoma 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Auburn vs. Oklahoma, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!