Auburn vs. LSU odds, line, spread: Proven model reveals college basketball picks, predictions for Dec. 29, 2021

An SEC battle is on tap between the No. 11 Auburn Tigers and the No. 16 LSU Tigers at 7 p.m. ET on Wednesday at Auburn Arena. Auburn is 11-1 overall and 6-0 at home, while LSU is 12-0 overall and 0-0 on the road. LSU is one of just five teams in the country that has not lost a game this season. 

Auburn is favored by 4 points in the latest Auburn vs. LSU odds from Caesars Sportsbook, while the over-under is set at 142. Before you make any LSU vs. Auburn picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Auburn vs. LSU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Auburn vs. LSU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.