The Athletics go for the series win when they take on the Minnesota Twins in an American League matchup on Thursday afternoon. The Athletics (58-70), who have won seven of 10, are 32-33 on the road this season. The Twins (58-68), who have dropped seven of 10, are 33-30 on their home field in 2025.

First pitch from Target Field in Minneapolis is set for 1:10 p.m. ET. The Twins have won five of the past eight meetings with the Athletics. Minnesota is a -116 favorite on the money line (risk $116 to win $100) in the latest Athletics vs. Twins odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 9.5 in the latest MLB odds. 

Before you make any Athletics vs. Twins picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 22 of the 2025 MLB season a profitable 33-24 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following could have seen strong returns!

The model has simulated Athletics vs. Twins 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Athletics vs. Twins, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 33-24 roll on top-rated MLB money-line picks!