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Astros vs. Red Sox odds, line, start time, picks, best bets for August 3 matchup from proven model

SportsLine's projection model, which is on a 27-22 roll on top-rated MLB money-line picks, has locked in its MLB picks for the Houston vs. Boston on Sunday

ByUpdated: Aug 03, 2025 12:33PM UTC . 2 min read

The Boston Red Sox (61-51) and the Houston Astros (62-49) finish their three-game series on Sunday. Boston is looking for the sweep, defeating Houston 7-3 in its last outing. Lucas Giolito (7-2, 3.80 ERA) grabs the ball for the Red Sox, and Framber Valdez (11-4, 2.62 ERA) does the same for the Astros. 

First pitch is scheduled for 11:35 a.m. ET at Fenway Park in Boston. The Astros are the -130 money-line favorites (risk $130 to win $100) in the latest Astros vs. Red Sox odds, while the Red Sox are +110 underdogs (risk $100 to win $110). The over/under for total runs scored is 8.5 in the latest MLB odds. 

Before you make any Astros vs. Red Sox picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 19 of the 2025 MLB season a profitable 27-22 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following could have seen strong returns!

The model has simulated Astros vs. Red Sox 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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Richard Louis

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